Condition Setting for Oral Mucosal Irritation Evaluation using Hamster Cheek Pouch
نویسندگان
چکیده
منابع مشابه
Carcinogenesis in the Hamster Cheek Pouch
Pouches from three experimental and one control animal were excised for analysis at various times during the first week and thereafter each week of carcinogen application (9,10-dimethyl-l ,~-benzanthracene) until the 131h week, at which time large tumors were present in all remaining aninmls. IIistologic progression from normal through inflanmmtion, uniform hyperplasia, localized premalignant h...
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OBJECTIVES Estrogen has been shown to play an important protective role in non-reproductive systems, such as the cardiovascular system. Our aim was to observe gender differences in vivo with regard to the increase in macromolecular permeability and leukocyte-endothelium interaction induced by ischemia/reperfusion as well as in microvascular reactivity to vasoactive substances using the hamster ...
متن کاملBoron neutron capture therapy for the treatment of oral cancer in the hamster cheek pouch model.
We have proposed and validated the hamster cheek pouch model of oral cancer for boron neutron capture therapy (BNCT) studies and shown that boronophenylalanine delivers potentially therapeutic 36.9 +/- 17.5 ppm boron to tumor tissue with tumor:normal tissue and tumor:blood ratios of 2.4:1 and 3.2:1, respectively. Here we report the first evidence of the usefulness of BNCT for the treatment of o...
متن کاملPropagated vasodilation in the microcirculation of the hamster cheek pouch.
Propagated vasodilation has been observed in the peripheral vasculature and may be significant in integrating the behavior of terminal arterioles and larger vessels. We have studied the characteristics of propagated vasodilation induced by acetylcholine in the microcirculation of the cheek pouch of the golden hamster. The technique of microionophoresis was used as a means of achieving relativel...
متن کاملMelatonin prevents ischemia reperfusion injury in hamster cheek pouch microcirculation.
OBJECTIVE We used the hamster cheek pouch microcirculation to investigate the effects of melatonin (ME) on ischemia reperfusion (I-R) injury by in vivo microscopy. ME is a hormone produced by the pineal gland and is the most powerful and effective hydroxyl radical scavenger detected to date in vitro. The second aim was to determine the scavenger effect of ME in cheek pouch microcirculation when...
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ژورنال
عنوان ژورنال: Korean Journal of Environmental Health Sciences
سال: 2015
ISSN: 1738-4087
DOI: 10.5668/jehs.2015.41.6.405